Test Bank Robbins Basic Pathology 9ed by Elsevier Saunders Author, Kumar, Vinay., Abbas, Abul k. and Aster, Jon C (2013)
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*** HERE IS A SAMPLE FOR YOU TO CHECK OUT – NOT THE FULL CHAPTER ***
Kumar: Robbins Basic Pathology, 9th Edition
Chapter 2: Inflammation and Repair
1. Transmembrane adhesive heterodimeric proteins, composed of an and a ß chain, are expressed on activated leukocytes during inflammation. They bind primarily to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), both of which belong to the family of proteins known as
e. growth factors
Surface proteins expressed on activated leukocytes are integrins, and they bind to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which belong to the immunoglobulin family of proteins.
2. Which of the following mediators of inflammation has chemotactic properties and is increased in persons taking aspirin?
a. Thromboxane A2
b. Prostaglandin E2
c. Platelet-activating factor
d. Leukotriene B4
Leukotriene B4 is chemotactic. It is increased in persons who take aspirin, because aspirin inhibits the cyclooxygenase pathway, thus shunting more arachidonic acid early derivatives into the lipoxygenase pathway. This promotes the synthesis of leukotrienes.
3. A 2-year-old child known to suffer from recurrent bacterial infections and poor wound healing was found to have leukocyte adhesion molecule deficiency 1 (LAD-1). The leukocytes of this patient do not express CD18, a molecule classified as belonging to the family of
c. lectin type of vascular adhesion molecules
LAD-1 is characterized by a deficiency of CD18, a cell surface molecule that is a ß2 integrin. The infections occur because the defective leukocytes cannot adhere to endothelial cells, cannot spread and attach, and cannot phagocytose bacteria.
4. Bradykinin is produced from a high-molecular weight kininogen circulating in the blood. This reaction is mediated by
a. coagulation factor X
c. Hageman factor
d. complement C3
e. protein C
Kallikrein promotes the formation of bradykinin from the high-molecular weight kininogen.
5. Nitric oxide synthesis is augmented in endothelial cells by a calmodulin-mediated influx of which element?
Endothelial cell nitric oxide synthase is constitutively expressed at low levels, but it can be increased by a calmodulin-mediated influx of calcium into the endothelial cells.
6. Which of the following mediators of inflammation causes pain?
a. Nitric oxide
b. Complement C3a
d. Leukotriene B4
Bradykinin causes pain. Other pain-causing substances are substance P and prostaglandin E2.
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